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Less serious side effects include: This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. What is the most important information I should know about codeine and guaifenesin? Ask a doctor or pharmacist before using any other cough or cold medicine. Guaifenesin is contained in many combination medicines.

Taking certain products together can cause you to get too much guaifenesin. Check the label to see if a medicine contains an guaifenesin, or an expectorant.

Codeine and guaifenesin may impair your thinking or reactions. Ketamine and PCP are called "dissociative" drugs, which means they make you feel separated from your body or your environment, and they twist the way you think or feel about something or someone. Codeine attaches to the same cell receptors as opioids like heroin. High doses of promethazine-codeine cough syrup can produce euphoria similar to that produced by other opioid drugs.

Also, both codeine and promethazine depress activities in the central nervous system brain and spinal cord , which produces calming effects. Extra amounts of dopamine increase the feeling of pleasure and at the same time cause important messages to get lost, causing a range of effects from lack of motivation to serious health problems. Repeatedly seeking to experience that feeling can lead to addiction.

What happens to your body when you misuse cough or cold medicines? DXM misuse can cause: It may slightly increase the risk of birth defects if used during the first two months of pregnancy.

Also, using it for a long time or in high doses near the expected delivery date may harm the unborn baby. To lessen the risk, take the smallest effective dose for the shortest possible time. This medication passes into breast milk and may rarely have undesirable effects on a nursing infant , such as unusual sleepiness, difficulty feeding, trouble breathing , or unusual limpness. Breast -feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions See also Warning section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: Guaifenesin is available in both prescription and nonprescription products. Check the labels on all your medications carefully to make sure you are not taking more than one product that contains guaifenesin.

Tell your doctor or pharmacist if you are taking other products such as other opioid pain or cough relievers such as morphine , hydrocodone , alcohol, marijuana , drugs for sleep or anxiety such as alprazolam , lorazepam , zolpidem , muscle relaxants such as carisoprodol , cyclobenzaprine , or antihistamines such as cetirizine , diphenhydramine.

Check the labels on all your medicines such as allergy or cough -and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Examples include azole antifungals such as ketoconazole , bupropion , fluoxetine , macrolide antibiotics such as erythromycin , HIV medications such as ritonavir , paroxetine, quinidine , rifamycins such as rifabutin , rifampin , certain drugs used to treat seizures such as carbamazepine , phenytoin , among others.

This medication may interfere with certain laboratory tests e. Make sure laboratory personnel and all your doctors know you use this drug. Overdose If someone has overdosed and has serious symptoms such as passing out or trouble breathing , call Otherwise, call a poison control center right away.

US residents can call their local poison control center at Canada residents can call a provincial poison control center. Symptoms of overdose may include: Notes Do not share this product with others.

It is against the law. This medication has been prescribed for your current condition only. Do not use it later for another condition unless told to do so by your doctor. A different medication may be necessary in that case. Missed Dose If you are prescribed this medication on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.

Do not double the dose to catch up. Storage Store at room temperature away from light and moisture. Do not store in the bathroom. Do not freeze liquid forms of this medication.

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