Adverse events have been reported in breastfeeding infants. If treatment with fluoxetine is considered necessary, discontinuation of breastfeeding should be considered; however, if breastfeeding is continued, the lowest effective dose of fluoxetine should be prescribed.
Patients should be advised to avoid driving a car or operating hazardous machinery until they are reasonably certain that their performance is not affected. In common with other SSRIs the following undesirable effects have been seen: Body as a whole: Abnormal liver function tests have been reported rarely.
Very rare cases of idiosyncratic hepatitis. Headache, sleep abnormalities e. Hallucinations, manic reaction, confusion, agitation, anxiety and associated symptoms e. Urinary retention, urinary frequency Reproductive disorders: Sexual dysfunction delayed or absent ejaculation, anorgasmia , priapism, galactorrhoea. Alopecia, yawn, abnormal vision e. Other haemorrhagic manifestations e. Some cases were possibly due to the syndrome of inappropriate antidiuretic hormone secretion.
The majority of reports were associated with older patients, and patients taking diuretics or otherwise volume depleted. Dyspnoea may be the only preceding symptom. Epidemiological studies, mainly conducted in patients 50 years of age and older, show an increased risk of bone fractures in patients receiving SSRIs and TCAs.
The mechanism leading to this risk is unknown. Withdrawal symptoms seen on discontinuation of fluoxetine treatments: Discontinuation of fluoxetine commonly leads to withdrawal symptoms. Children and adolescents fluoxetine 60mg capsules are not licensed for use in children and adolescents but lower strength formulations are available for this patient population - see section 4. The following data were obtained from paediatric clinical trials: After 19 weeks of treatment, paediatric subjects treated with fluoxetine in a clinical trial gained an average of 1.
Isolated cases of growth retardation have also been reported from clinical use. Isolated cases of adverse events potentially indicating delayed sexual maturation or sexual dysfunction have been reported from paediatric clinical use. Symptoms of overdose have included nausea, vomiting, seizures, cardiovascular dysfunction ranging from asymptomatic arrhythmias to cardiac arrest, pulmonary dysfunction, and signs of altered CNS status ranging from excitation to coma.
Fatality attributed to overdose of fluoxetine alone has been extremely rare. Cardiac and vital signs monitoring are recommended, along with general symptomatic and supportive measures. No specific antidote is known. Forced diuresis, dialysis, haemoperfusion, and exchange transfusion are unlikely to be of benefit.
Activated charcoal, which may be used with sorbitol, may be as or more effective than emesis or lavage. In managing overdosage, consider the possibility of multiple drug involvement. An extended time for close medical observation may be needed in patients who have taken excessive quantities of a tricyclic antidepressant if they are also taking, or have recently taken, fluoxetine. Pharmacological properties Pharmcotherapeutic group: N06AB03 Fluoxetine is a selective inhibitor of serotonin reuptake, and this probably accounts for the mechanism of action.
Clinical trials in patients with major depressive episodes have been conducted versus placebo and active controls. In the fixed dose studies of patients with major depression there is a flat dose response curve, providing no suggestion of advantage in terms of efficacy for using higher than the recommended doses. However, it is clinical experience that uptitrating might be beneficial for some patients. In short-term trials under 24 weeks , fluoxetine was shown to be significantly more effective than placebo.
In long term studies three short term studies extension phase and a relapse prevention study efficacy has not been shown. However, for long-term efficacy no conclusion can be drawn. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine should come with a Medication Guide. It is very important that you read and understand this information.
Be sure to ask your doctor about anything you do not understand. You may take the medicine with or without food. For some conditions, it may take a month or longer before you begin to feel better.
If you are using the oral liquid, shake the bottle well before measuring each dose. Measure the liquid with a marked measuring spoon, oral syringe, or medicine cup. These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged 65 and older.
In patients of all ages who are started on antidepressant therapy, monitor closely for worsening and for emergence of suicidal thoughts and behavior. Advise families and caregivers of the need for close observation and communication with the prescriber. Fluoxetine is not approved for use in children less than 7 years of age. In addition, do not start fluoxetine in a patient who is being treated with linezolid or intravenous methylene blue due to risk of serotonin syndrome. Do not use fluoxetine with pimozide due to risk of QT interval prolongation and drug interaction.
Do not use fluoxetine with thioridazine due to risk of QT interval prolongation and elevated thioridazine plasma levels. Do not use thioridazine within 5 weeks of discontinuing fluoxetine. Do not use this fluoxetine product in patients with known hypersensitivity to fluoxetine due to risk of anaphylactoid reactions, including bronchospasm, angioedema, laryngospasm, and urticaria.
Is it possible for me to take Fluoxetine HCl with other drugs? Should certain beverages, foods and other products be avoided when I take Fluoxetine HCl? What are the possible drug interactions of Fluoxetine HCl? How will Fluoxetine HCl work in my body? How should Fluoxetine HCl be taken? Edgemont's Fluoxetine 60 mg tablet is the only fluoxetine product to offer a 60 mg dose in a single pill.
The tablets also have a functional score to allow for a convenient half-tablet 30 mg dosing option. Until now, patients requiring a 30 mg or 60 mg dose of fluoxetine have needed to take three 10 mg pills or three 20 mg pills to achieve their target dose.
Numerous published studies have also demonstrated a statistically significant improvement in patient therapy adherence when the number of pills per dose is reduced 1. This is an especially important goal for the higher milligram dose patients that may be having trouble controlling their symptoms of depression," said Douglas Saltel, President and CEO of Edgemont. Edgemont's goal is to ensure broad patient access by aggressively pricing its Fluoxetine 60 mg Tablets in the range of generics.
Edgemont expects to begin shipping product in approximately four weeks. For a full copy of the package insert, go to:
This finding would appear to be supported by clinical findings. Elderly The daily dose should generally not exceed 40 mg. It may take amoxicillin target pharmacy prozac or more to see any effects. As in adults, fluoxetine and norfluoxetine accumulated extensively following 60mg oral prozac steady-state concentrations were achieved within 3 to 4 weeks of daily dosing. What is fluoxetine, and how does it work mechanism of action? Safety of co-administration of doses above 18 mg olanzapine with 75 mg fluoxetine has not been evaluated in clinical studies, prozac 60mg. When fluoxetine is used in combination with lithium, closer and more frequent clinical monitoring is required, prozac 60mg. Do 60mg take a double dose to make up for a forgotten dose. Drugs that may lower sodium concentration in the blood e.
Treatment should consist of those general measures employed in the management of overdosage with any drug, prozac 60mg. This is an especially important goal for the higher milligram dose patients that may be having trouble controlling their symptoms of depression," said Douglas Saltel, President and CEO of Edgemont. The S-fluoxetine enantiomer is eliminated more slowly and is fosamax bone disorder predominant enantiomer present in plasma at steady state, prozac 60mg. PROZAC should be used with caution in patients with congenital long QT syndrome ; a previous history of QT 60mg a family history of long QT syndrome or sudden cardiac death; and other conditions that predispose to QT prolongation and ventricular arrhythmia. Since the introduction of PROZAC, systemic reactions, 60mg related to vasculitis and including lupus -like syndrome, have developed in patients with rash. Serotonin is one neurotransmitter that is released by nerves in the brain. When treating a pregnant woman with PROZAC, the physician should carefully consider both the potential risks of taking an SSRI, along with the established benefits of treating depression with an antidepressant. Patients 60mg be monitored for the emergence of serotonin syndrome. Patients should be monitored for these symptoms when discontinuing treatment with fluoxetine. Patients of all ages who are prozac on antidepressant therapy should be monitored appropriately prozac observed closely for clinical worsening, suicidality, prozac unusual changes in behavior. The following information includes only the average doses of this medicine, prozac 60mg. Such monitoring should include daily observation by families and caregivers.
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